A prodrug form of the pro-apoptotic compound cRIPGBM; converted to cRIPGBM in GBM-1 GBM CSCs but not primary HLFs; induces apoptosis in GBM CSCs (EC50 = ≤500 nM); selectively reduces survival of GBM-1 cells (EC50 = 0.22 μM) over human neural stem cells

RIPGBM – 10 mg

Brand:
Cayman
CAS:
355406-76-7
Storage:
-20
UN-No:
- /

RIPGBM is a prodrug form of the pro-apoptotic compound cRIPGBM.{35798} It is converted to cRIPGBM in GBM-1 glioblastoma multiforme (GBM) cancer stem cells (CSCs) but not primary human lung fibroblasts (HLFs). RIPGBM induces apoptosis in GBM CSCs (EC50 = ≤500 nM) and selectively reduces survival of GBM-1 cells (EC50 = 0.22 μM) over human neural stem cells, primary human astrocytes, and primary HLFs (EC50s = 1.7, 2.9, and 3.5 μM, respectively). It reduces tumor growth in a GBM mouse xenograft model using patient-derived GBM-39 cells engineered to express IR fluorescent protein 720 (IRFP720) when administered at a dose of 50 mg/kg twice per day.  

 

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Description

A prodrug form of the pro-apoptotic compound cRIPGBM; converted to cRIPGBM in GBM-1 GBM CSCs but not primary HLFs; induces apoptosis in GBM CSCs (EC50 = ≤500 nM); selectively reduces survival of GBM-1 cells (EC50 = 0.22 μM) over human neural stem cells, primary human astrocytes, and primary HLF cells (EC50s = 1.7, 2.9, and 3.5 μM, respectively); reduces tumor growth in a GBM mouse xenograft model using patient-derived GBM-39 cells engineered to express IRFP720 at 50 mg/kg twice per day

Formal name: N-[1,4-dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]-acetamide

Synonyms: 

Molecular weight: 428.5

CAS: 355406-76-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death

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