A potent and selective CB1 receptor antagonist (Kis = 5.6 and >1

Rimonabant – 5 mg

Brand:
Cayman
CAS:
168273-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rimonabant is a potent and selective cannabinoid (CB) receptor 1 antagonist (Kis = 5.6 and >1,000 nM for CB1 and CB2, respectively).{3133} In rodent models, rimonabant induces lipolysis, reduces hepatomegaly, decreases body weight, and improves dyslipidemia by reducing triglyceride, free fatty acid, and total cholesterol levels and by increasing HDL/LDL ratios.{17168} Rimonabant elicits antiproliferative and immunomodulatory effects (e.g., cell cycle arrest, increased expression of IκB and phosphorylated Akt, and decreased expression of NF-κB, phosphorylated ERK1/2, COX-2, and iNOS) in vitro.{17167}  

 

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SKU: 9000484 - 5 mg Category:

Description

A potent and selective CB1 receptor antagonist (Kis = 5.6 and >1,000 nM for CB1 and CB2, respectively); induces lipolysis, reduces hepatomegaly, decreases body weight, and improves dyslipidemia by reducing triglyceride, free fatty acid, and total cholesterol levels and by increasing HDL/LDL ratios in rodent models; elicits antiproliferative and immunomodulatory effects in vitro,

Formal name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

Synonyms:  SR141716

Molecular weight: 463.8

CAS: 168273-06-1

Purity: ≥98%

Formulation: A crystalline solid

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