An orally bioavailable CGRP receptor antagonist (Ki = 0.027 nM); inhibits α-CGRP-stimulated cAMP production in SK-N-MC human neuroblastoma cells (IC50 = 0.14 nM); reduces human α-CGRP-induced increases in facial blood flow

Rimegepant – 5 mg

Brand:
Cayman
CAS:
1289023-67-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rimegepant is an orally bioavailable antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 0.027 nM).{47524} It inhibits cAMP production stimulated by α-CGRP (Item No. 24405) in SK-N-MC human neuroblastoma cells (IC50 = 0.14 nM). Rimegepant (7 mg/kg, s.c.) reduces human α-CGRP-induced increases in facial blood flow, a surrogate for changes in intracranial artery diameter, in anesthetized marmosets.  

 

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SKU: 26338 - 5 mg Category:

Description

An orally bioavailable CGRP receptor antagonist (Ki = 0.027 nM); inhibits α-CGRP-stimulated cAMP production in SK-N-MC human neuroblastoma cells (IC50 = 0.14 nM); reduces human α-CGRP-induced increases in facial blood flow, a surrogate for changes in intracranial artery diameter, in anesthetized marmosets at 7 mg/kg

Formal name: 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylic acid, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester

Synonyms:  BMS-927711

Molecular weight: 534.6

CAS: 1289023-67-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience|Pain Research

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