Description
A derivative of amantadine with antiviral activity; inhibits recombinant influenza A M2 protein expressed in X. laevis oocytes (IC50 = 10.8 µM); inhibits recombinant HCV p7 protein expressed in HEK293 cells (IC50s = 0.7, 24, 1.6, and 3.0 nM for HCV genotypes 1a, 2a, 3a, and 4a, respectively); inhibits cytotoxicity induced by the influenza A strains A/PR/8/34 (H1N1) and A/HK/7/87 (H3N2), but not the influenza B strain B/HK/72, in MDCK cells (EC50s = 18, 0.62, and >500 µM, respectively); increases the survival rate of mice infected with the influenza A strain infected with the influenza A strain A2/Jap/305 from 20 to 90% at 24 mg/kg when administered two hours post-infection; has trypanocidal activity against bloodstream forms of T. brucei in vitro (IC50 = 1.26 µg/ml)
Formal name: α-methyl-tricyclo[3.3.1.13,7]decane-1-methanamine, monohydrochloride
Synonyms: 1-(1-Adamantyl)ethylamine Hydrochloride|NSC 206764
Molecular weight: 215.8
CAS: 1501-84-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|Influenza
