A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate

Riluzole (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
850608-87-6
Storage:
22
UN-No:
De Minimis - 2811 / 6.1

Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM).{22851} Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg.{22851} Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.{22851}  

 

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Description

A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED50 = 3.2 mg/kg) and displays neuroprotective effects in hypoxic animals (ED50 = 4 mg/kg)

Formal name: 6-(trifluoromethoxy)-2-benzothiazolamine, monohydrochloride

Synonyms:  PK 26124

Molecular weight: 270.7

CAS: 850608-87-6

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Seizure Disorders

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