A non-nucleoside reverse transcriptase inhibitor; inhibits growth of wild-type (EC50 = 0.51 nM) and NNRTI-resistant HIV strains (EC50s =

Rilpivirine – 10 mg

Brand:
Cayman
CAS:
500287-72-9
Storage:
-20
UN-No:
Non-Hazardous - /

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.{35241} It is active against NNRTI-resistant HIV strains with EC50 values less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Item No. 18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.{35242}  

 

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Description

A non-nucleoside reverse transcriptase inhibitor; inhibits growth of wild-type (EC50 = 0.51 nM) and NNRTI-resistant HIV strains (EC50s = <1 nM for L100I, K103N, V106A, G190A, and G190S mutants); reduces the plasma viral titer in HIV-1 infected humanized mice when used in combination with cabotegravir, lamivudine, and abcavir

Formal name: 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-benzonitrile

Synonyms:  R278474|TMC278

Molecular weight: 366.4

CAS: 500287-72-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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