A rifamycin antibiotic; inhibits bacterial RNA polymerase (IC50 = 0.01 μg/ml for the E. coli enzyme); inhibits the growth of M. tuberculosis H37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species of Staphylococcus

Rifampicin – 500 mg

Brand:
Cayman
CAS:
13292-46-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50 = 0.01 μg/ml for the E. coli enzyme).{23992} It inhibits the growth of M. tuberculosis H37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species of Staphylococcus, Streptococcus, Haemophilus, and Neisseria (MICs = 0.009-1.4 μg/ml).{40531,32022} Rifampicin increases survival in a mouse model of tuberculosis infection.{32022} It is also an agonist of the human pregnane X receptor (PXR; EC50 = ~2 μM).{23996} Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.  

 

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Description

A rifamycin antibiotic; inhibits bacterial RNA polymerase (IC50 = 0.01 μg/ml for the E. coli enzyme); inhibits the growth of M. tuberculosis H37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species of Staphylococcus, Streptococcus, Haemophilus, and Neisseria (MICs = 0.009-1.4 μg/ml); increases survival in a mouse model of tuberculosis infection; an agonist of the human PXR (EC50 = ~2 μM)

Formal name: 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin

Synonyms:  NIH 10782|NSC 113926|Rifampin

Molecular weight: 823

CAS: 13292-46-1

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Rifamycins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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