An LTB4 receptor antagonist (Ki = 2 µM); inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s = 10 and 7 µM

Ricinelaidic Acid – 250 mg

Brand:
Cayman
CAS:
540-12-5
Storage:
-20
UN-No:
- 1170 / 3

Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 µM in porcine neutrophil membranes).{2361} It inhibits chemotaxis and calcium flux induced by LTB4 (Item No. 20110) in isolated human neutrophils (IC50s = 10 and 7 µM, respectively). Ricinelaidic acid (1 mg/kg, i.v.) inhibits bronchoconstriction induced by LTB4 in rats by 46%.  

 

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Description

An LTB4 receptor antagonist (Ki = 2 µM); inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s = 10 and 7 µM, respectively); inhibits bronchoconstriction induced by LTB4 in rats by 46%

Formal name: 12(R)-hydroxy-9(E)-octadecenoic acid

Synonyms: 

Molecular weight: 298.5

CAS: 540-12-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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