An antiviral nucleoside analog; metabolized to an active triphosphate form that induces viral chain termination and inhibits viral polymerases; reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml); reduces replication of SARS-CoV-2 in Vero cells (EC50 = 109.5 µM); aerosol administration reduces mortality in a mouse model of influenza A infection at 30 mg/kg

Ribavirin – 500 mg

Brand:
Cayman
CAS:
36791-04-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.  

 

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Description

An antiviral nucleoside analog; metabolized to an active triphosphate form that induces viral chain termination and inhibits viral polymerases; reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml); reduces replication of SARS-CoV-2 in Vero cells (EC50 = 109.5 µM); aerosol administration reduces mortality in a mouse model of influenza A infection at 30 mg/kg

Formal name: 1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

Synonyms:  NSC 163039

Molecular weight: 244.2

CAS: 36791-04-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Infectious Disease|Viral Diseases|RSV Infections

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