Competitively inhibits IMPDH in vitro (Ki = 270 nM); a metabolite of the prodrug ribavirin; broad-spectrum antiviral activity

Ribavirin 5′-monophosphate (lithium salt) – 1 mg

Brand:
Cayman
CAS:
66983-94-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ribavirin 5′-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.{34338,34337,29247} This agent, a metabolite of the prodrug ribavirin (Item No. 16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses.{34337,29247} The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase.{34338,29247} The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5′-monophosphate.{34335,34336}  

 

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Description

Competitively inhibits IMPDH in vitro (Ki = 270 nM); a metabolite of the prodrug ribavirin; broad-spectrum antiviral activity, particularly against influenza and HIV

Formal name: 1-(5-O-phosphono-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, dilithium salt

Synonyms: 

Molecular weight: 336.1

CAS: 66983-94-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Infectious Disease|Viral Diseases|Influenza

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