A RAD51 inhibitor (IC50s = 5-30 µM); selectively inhibits homologous recombination without inhibiting single strand annealing; sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks

RI-1 – 1 mg

Brand:
Cayman
CAS:
415713-60-9
Storage:
-20
UN-No:
Non-Hazardous - /

RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.{40763,31181} RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing.{40763} It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM).{40763,31181}  

 

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SKU: 24182 - 1 mg Category:

Description

A RAD51 inhibitor (IC50s = 5-30 µM); selectively inhibits homologous recombination without inhibiting single strand annealing; sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD50 = 16.62 µM)

Formal name: 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

Synonyms: 

Molecular weight: 361.6

CAS: 415713-60-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair

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