A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can inhibit oxidative phosphorylation; ex/em = 507/529 nm

Rhodamine 123 (chloride) – 10 mg

Brand:
Cayman
CAS:
62669-70-9
Storage:
-20
UN-No:
Non-Hazardous - /

Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}  

 

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Description

A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can inhibit oxidative phosphorylation; ex/em = 507/529 nm

Formal name: 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-xanthylium, monochloride

Synonyms:  R-22420|R-302|RH123

Molecular weight: 380.8

CAS: 62669-70-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Cell Biology|Stem Cell Research

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