An anthraquinone glycoside; increases the rate of sennoside A metabolism by mouse intestinal bacteria in vitro at 0.03-1 mM; increases the purgative activity of sennoside A in mice in a dose-dependent manner; inhibits PTP1B (IC50 = 11.5 μM); metabolized to rhein by intestinal bacteria

Rhein-8-glucoside – 1 mg

Brand:
Cayman
CAS:
34298-86-7
Storage:
-20
UN-No:
Non-Hazardous - /

Rhein-8-glucoside is an anthraquinone glycoside that has been found in rhubarb.{46524} It increases the rate of sennoside A (Item No. 24969) metabolism by mouse intestinal bacteria in vitro when used at concentrations ranging from 0.03 to 1 mM. Rhein-8-glucoside increases the purgative activity of sennoside A in mice in a dose-dependent manner. It also inhibits human protein tyrosine phosphatase (PTP1B; IC50 = 11.5 μM).{46525} Rhein-8-glucoside is metabolized to rhein (Item No. 17345) by intestinal bacteria.{46524}  

 

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SKU: 28844 - 1 mg Category:

Description

An anthraquinone glycoside; increases the rate of sennoside A metabolism by mouse intestinal bacteria in vitro at 0.03-1 mM; increases the purgative activity of sennoside A in mice in a dose-dependent manner; inhibits PTP1B (IC50 = 11.5 μM); metabolized to rhein by intestinal bacteria

Formal name: 5-(β-D-glucopyranosyloxy)-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Synonyms:  Rhein 8-O-β-D-glucopyranoside

Molecular weight: 446.4

CAS: 34298-86-7

Purity: ≥98%

Formulation: A crystalline solid

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