Description
An anthraquinone derivative; induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells at 40 and 100 µM, respectively; inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions at 100 and 200 µM; reduces controlled cortical impact-induced decreases in catalase and SOD activity and MDA, glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury at 12 mg/kg; reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein at 50 mg/kg per day
Formal name: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Synonyms: NSC 38629|Rheic Acid
Molecular weight: 284.2
CAS: 478-43-3
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Natural Products|Anthraquinones||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
