A selective inhibitor of diacylglycerol lipase (IC50 = 4 µM) that demonstrates relatively weak inhibition of phospholipases A2 and C; elevates the concentration of diacylglycerol

RHC-80267 – 10 mg

Brand:
Cayman
CAS:
83654-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

Diacylglycerol (DAG) is an important cellular source of arachidonic acid (Item No. 90010) which may be released by the action of DAG lipase (DAGL). RHC-80267 is a selective inhibitor of DAGL (IC50 = 4 µM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C.{27089} By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C.{27090} At 0.3-1 µM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.{27090}  

 

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Description

A selective inhibitor of diacylglycerol lipase (IC50 = 4 µM) that demonstrates relatively weak inhibition of phospholipases A2 and C; elevates the concentration of diacylglycerol, which leads to activation of PKC

Formal name: 1,1’-[O,O’-[1,6-hexanediylbis(iminocarbonyl)]dioxime]

Synonyms:  U-57908

Molecular weight: 394.5

CAS: 83654-05-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Lipid Biochemistry|Glycerolipids|Lipases

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