A flavonoid with diverse biological activities; reduces miconazole-induced production of ROS and apoptosis in H9c2 cardiomyocytes; inhibits LPS-induced TNF-α and NO production in OHSCs under control conditions and during ethanol withdrawal

Rhamnetin – 5 mg

Brand:
Cayman
CAS:
90-19-7
Storage:
-20
UN-No:
Non-Hazardous - /

Rhamnetin is a flavonoid that has been found in O. falcate and has diverse biological activities.{61082,33775,33776,33774} It reduces production of reactive oxygen species (ROS) and apoptosis induced by miconazole (Item No. 15420) in H9c2 cardiomyocytes.{33775} Rhamnetin inhibits LPS-induced TNF-α and nitric oxide (NO) production in rat neonatal organotypic hippocampal slice cultures (OHSCs) under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal.{33776} Dietary administration of rhamnetin (0.1 and 0.2% w/w) reduces serum levels of malondialdehyde (MDA) and liver and erythrocyte levels of thiobarbituric acid reactive substances (TBARS) in rats fed a cholesterol-free diet.{33774} Rhamnetin increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury.{33777}  

 

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Description

A flavonoid with diverse biological activities; reduces miconazole-induced production of ROS and apoptosis in H9c2 cardiomyocytes; inhibits LPS-induced TNF-α and NO production in OHSCs under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal; reduces serum levels of MDA and liver and erythrocyte levels of TBARS in rats fed a cholesterol-free diet; increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury

Formal name: 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one

Synonyms:  7-Methoxyquercetin|7-Methylquercetin|CI-75690|LY805921|NSC 19802|β-Rhamnocitrin

Molecular weight: 316.3

CAS: 90-19-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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