An HDAC1 and HDAC3 inhibitor (IC50s = 60 and 50 nM; Kis = 32 and 5 nM

RGFP109 – 5 mg

Brand:
Cayman
CAS:
1215493-56-3
Storage:
-20
UN-No:
Non-Hazardous - /

RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).{33565} It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.{33565}  

 

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Description

An HDAC1 and HDAC3 inhibitor (IC50s = 60 and 50 nM; Kis = 32 and 5 nM, respectively); upregulates frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia

Formal name: N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide

Synonyms:  RG-2833

Molecular weight: 339.4

CAS: 1215493-56-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience

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