A purine derivative; induces differentiation or dedifferentiation

Reversine – 1 mg

Brand:
Cayman
CAS:
656820-32-5
Storage:
-20
UN-No:
Non-Hazardous - /

Reversine is a 2,6-disubstituted purine derivative that was originally found to induce dedifferentiation of C2C12 culture myoblast cells into stem cell progenitors when used at a concentration of 5 µM for four days.{12913} Depending on cell type, reversine promotes either differentiation or dedifferentiation. For example, in NT2 neuronal and HL-60 human promyelocytic leukemia cells, it induces differentiation.{38283} It inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM and acts as an antagonist at the adenosine A3 receptor with a Ki value of 0.66 µM.{38283,13281,38284} Reversine is also used for studies of chromosome segregation. It inhibits the mitotic spindle checkpoint enzyme MPS1 with IC50 values of 6 and 2.8 nM for its kinase domain and full-length version, respectively).{38284} Reversine induces autophagy in WRO human follicular thyroid cancer cells and decreases Akt/mTOR signaling.{34281}  

 

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SKU: 10004412 - 1 mg Category:

Description

A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1 (IC50s = 6 and 2.8 nM for its kinase domain and full-length version, respectively); induces autophagy in WRO human follicular thyroid cancer cells; decreases Akt/mTOR signaling,

Formal name: N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine

Synonyms: 

Molecular weight: 393.5

CAS: 656820-32-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Stem Cell Research|Differentiation

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