A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM)

Reversin 121 – 5 mg

Brand:
Cayman
CAS:
174630-04-7
Storage:
-20
UN-No:
Non-Hazardous - /

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM.{30974,30795} Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.{30974}  

 

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Description

A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM)

Formal name: 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester N-[(1,1-dimethylethoxy)carbonyl]-L-a-aspartyl-N6-[(phenylmethoxy)carbonyl]-L-lysine

Synonyms: 

Molecular weight: 641.8

CAS: 174630-04-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance

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