A polyketide with antifungal activity against C. albicans (MICs = 2.0 and >500 µg/ml at pH 3 and 7.4

Reveromycin C – 1 mg

Brand:
Cayman
CAS:
144860-69-5
Storage:
-20
UN-No:
Non-Hazardous - /

Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs = 2.0 and >500 µg/ml at pH 3 and 7.4, respectively).{36572,28254} Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line.{28254} It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50 = 1.58 µg/ml) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50 = 2.0 µg/ml for both).{28254}  

 

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SKU: 23488 - 1 mg Category:

Description

A polyketide with antifungal activity against C. albicans (MICs = 2.0 and >500 µg/ml at pH 3 and 7.4, respectively); inhibits EGF-induced mitogenic activity in Balb/MK mouse epidermal cells; reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50 = 1.58 µg/ml); inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50 = 2.0 µg/ml for both)

Formal name: butanedioic acid, 1-[(2S,3R,6S,8R,9S)-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-3-(3-methylbutyl)-1,7-dioxaspiro[5.5]undec-3-yl] ester

Synonyms: 

Molecular weight: 674.8

CAS: 144860-69-5

Purity: ≥95%

Formulation: A lyophilisate

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Polyketides||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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