A selective inhibitor of retrograde protein trafficking mediated by syntaxin-5; inhibits ebolavirus infection (EC50 = 12.2 µM) in HeLa cells; reduces ricin-induced toxicity in HeLa cells (20 µM); blocks JC polyomavirus

Retro-2 – 25 mg

Brand:
Cayman
CAS:
1429192-00-6
Storage:
-20
UN-No:
Non-Hazardous - /

Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways.{38929,38932} Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 µM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 µM in HeLa cells.{38932,38931} Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 µM, respectively).{38928} In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.{38932,38930}  

 

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Description

A selective inhibitor of retrograde protein trafficking mediated by syntaxin-5; inhibits ebolavirus infection (EC50 = 12.2 µM) in HeLa cells; reduces ricin-induced toxicity in HeLa cells (20 µM); blocks JC polyomavirus, BK polyomavirus, and SV40 infection of Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 µM, respectively); improves survival and reduces symptoms in mice infected with Shiga toxin-producing E. coli (100 mg/kg, i.p.); protects mice against ricin challenge when administered prophylactically (2 mg/kg),

Formal name: 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone

Synonyms: 

Molecular weight: 320.4

CAS: 1429192-00-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Ebola

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