A cAMP phosphodiesterase inhibitor (IC50 = 41 µM); inhibits DNA topoisomerase I at a concentration of 45 µM in B16F10 melanoma cells; has antifungal activity against T. mentagrophyes with a MIC 1.8 µM; cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 µM

Reticulol – 5 mg

Brand:
Cayman
CAS:
26246-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 µM).{41097,41096} It also inhibits DNA topoisomerase I when used at a concentration of 45 µM in B16F10 melanoma cells.{41098} Reticulol has antifungal activity against T. mentagrophyes with a MIC of 1.8 µM.{41099} It is cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 µM, respectively, and inhibits lung metastasis in mice.{41099}  

 

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SKU: 23148 - 5 mg Category:

Description

A cAMP phosphodiesterase inhibitor (IC50 = 41 µM); inhibits DNA topoisomerase I at a concentration of 45 µM in B16F10 melanoma cells; has antifungal activity against T. mentagrophyes with a MIC 1.8 µM; cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 µM, respectively; inhibits lung metastasis in mice

Formal name: 6,8-dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one

Synonyms:  6,8-dihydroxy-7-methoxy-3-methyl Isocoumarin|NSC 294978

Molecular weight: 222.2

CAS: 26246-41-3

Purity: >95%

Formulation: A powder

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|cAMP Signaling||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Ringworm

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