An inhibitor of RET kinase (IC50 = 0.4 nM); selective for RET kinase over VEGFR2/KDR (IC50 = 109 nM); reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at 10 mg/kg twice per day

RET Kinase Inhibitor 1 – 25 mg

Brand:
Cayman
CAS:
1627856-64-7
Storage:
-20
UN-No:
Non-Hazardous - /

RET kinase inhibitor 1 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM).{45511} It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). RET kinase inhibitor 1 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.  

 

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SKU: 24023 - 25 mg Category:

Description

An inhibitor of RET kinase (IC50 = 0.4 nM); selective for RET kinase over VEGFR2/KDR (IC50 = 109 nM); reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at 10 mg/kg twice per day

Formal name: 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-benzeneacetamide

Synonyms: 

Molecular weight: 467.4

CAS: 1627856-64-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Gastric Disease|IBS

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