Resveratrol-3-O-Sulfate (sodium salt) – 500 µg

Brand:
Cayman
CAS:
858127-11-4
Storage:
-20
UN-No:
Non-Hazardous - /

Resveratrol-3-O-sulfate is a metabolite of resveratrol (Item Nos. 70675 | 10004235).{37575} In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 µM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 µM, and induces apoptosis at concentrations of 25 and 50 µM.{37576} Resveratrol-3-O-sulfate also displaces rosiglitazone (Item No. 71740) from the outer mitochondrial protein mitoNEET (IC50 = 3.36 µM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.{37577}  

 

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Description

An active metabolite of resveratrol; decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, in U-937 macrophages at 1 µM; decreases growth of Caco-2 cells at 10-100 µM and induces apoptosis at 25 and 50 µM; binds to mitoNEET (IC50 = 3.36 µM) in the TZD binding pocket,


Formal name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol, 1-(hydrogen sulfate), monosodium salt

Synonyms: 

Molecular weight: 330.3

CAS: 858127-11-4

Purity: ≥95%

Formulation: A solid


Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|JNK||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Activators|Deacetylases||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity