An SPM; produced from EPA by 15-LO via 15(S)-HpEPE and 15S-hydroxy

Resolvin E4 – 100 µg

Brand:
Cayman
CAS:
1781227-87-9
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.{50723} It is produced from eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908) by 15-lipoxygenase (15-LO) via 15(S)-HpEPE (Item No. 42710) and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism. It has been found in mouse inflammatory exudates. RvE4 (10 nM) increases efferocytosis of apoptotic neutrophils or senescent red blood cells (sRBCs) by human M2 macrophages under hypoxic conditions in vitro. Intraperitoneal administration of RvE4 (100 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of hemorrhagic peritonitis induced by zymosan A (Item No. 21175) and thrombin. It also increases inflammatory exudate macrophage infiltration and efferocytosis of apoptotic neutrophils and/or RBCs in the same model.  

 

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SKU: 29590 - 100 µg Category:

Description

An SPM; produced from EPA by 15-LO via 15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human M2 macrophages or PMN neutrophils under normoxic or hypoxic conditions; enhanced synthesis in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism; has been found in mouse inflammatory exudates; increases efferocytosis of apoptotic neutrophils or sRBCs by human M2 macrophages under hypoxic conditions in vitro; inhibits zymosan A- and thrombin-induced increases in inflammatory exudate neutrophil infiltration in a mouse model of hemorrhagic peritonitis at 100 ng/animal; increases inflammatory exudate macrophage infiltration and efferocytosis of apoptotic neutrophils and/or RBCs in the same model

Formal name: 5S,15S-dihydroxy-6E,8Z,11Z,13E,17Z-eicosapentaenoic acid

Synonyms:  RvE4

Molecular weight: 334.5

CAS: 1781227-87-9

Purity: ≥95%

Formulation: A solution in ethanol

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