A DHA-derived resolvin that stimulates the phagocytosis of E. coli by human macrophages

Resolvin D5 – 50 µg

Brand:
Cayman
CAS:
578008-43-2
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.{14974} RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in exudates of bacterial infections in mice.{15180,30501,30500} RvD5 stimulates the phagocytosis of E. coli by human macrophages, and RvD5 methyl ester enhances bacterial killing in mice inoculated with E. coli.{30500} Analytical and biological comparisons of synthetic RvD5 with endogenously derived RvD5 have confirmed its identity as matching the natural product.{14569}  

 

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SKU: 10007280 - 50 µg Category:

Description

A DHA-derived resolvin that stimulates the phagocytosis of E. coli by human macrophages

Formal name: 7S,17S-dihydroxy-4Z,8E,10Z,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  7(S),17(S)-diHDHA|7(S),17(S)-Resolvin D5|RvD5

Molecular weight: 360.5

CAS: 578008-43-2

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience

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