A pro-resolving mediator that reduces neutrophil infiltration in vivo and promotes phagocytosis of bacteria

Resolvin D4 – 10 µg

Brand:
Cayman
CAS:
1025684-60-9
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid (Item No. 90310).{18022} It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.{32237,30353} RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection.{30353} With isolated cells, RvD4 promotes phagocytosis of bacteria, opsonized zymosan A, and apoptotic neutrophils by human macrophages.{30353} It also promotes the clearance of apoptotic neutrophils by human fibroblasts.{30353}  

 

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Description

A pro-resolving mediator that reduces neutrophil infiltration in vivo and promotes phagocytosis of bacteria, opsonized zymosan A, and apoptotic neutrophils by human macrophages

Formal name: 4S,5,17S-trihydroxy-6E,8E,10E,13E,15Z,19Z-docosahexaenoic acid

Synonyms:  RvD4

Molecular weight: 376.5

CAS: 1025684-60-9

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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