A DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis

Resolvin D3 – 25 µg

Brand:
Cayman
CAS:
916888-47-6
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response.{14973} Resolvin D3 (RvD3) is a DHA-derived product first identified in mouse inflammatory exudates.{11433} It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation.{11433} In addition to suppressing leukocyte migration, RvD3 enhances macrophage phagocytosis and efferocytosis.{29714} Unlike other resolvins, RvD3 appears late in resolution in mouse peritonitis.{29714,29715} Analytical and biological comparisons of synthetic RvD3 with endogenously derived RvD3 have confirmed its identity as matching the natural product.{14569}  

 

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Description

A DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis

Formal name: 4S,11R,17S-trihydroxy-5Z,7E,9E,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  RvD3

Molecular weight: 376.5

CAS: 916888-47-6

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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