An internal standard for the quantification of RvD2 by GC- or LC-MS

Resolvin D2-d5 – 10 µg

Brand:
Cayman
CAS:
1881277-33-3
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209}  

 

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SKU: 11184 - 10 µg Category:

Description

An internal standard for the quantification of RvD2 by GC- or LC-MS

Formal name: 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21’,22,22,22-d5 docosahexaenoic acid

Synonyms:  7(S),16(R),17(S)-Resolvin D2-d5|RvD2-d5

Molecular weight: 381.5

CAS: 1881277-33-3

Purity: ≥95%

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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