Dampens excessive neutrophil trafficking to sites of inflammation; reduces neutrophil infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces leukocyte adherence and emigration at 1 nM

Resolvin D2 – 10 µg

Brand:
Cayman
CAS:
810668-37-2
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 (RvD2) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, RvD2 dose dependently decreases leukocyte-endothelial interactions. In a mouse model of sepsis, RvD2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209} Analytical and biological comparisons of synthetic RvD2 with endogenously derived RvD2 have confirmed its identity as matching the natural product.{14569}  

 

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SKU: 10007279 - 10 µg Category:

Description

Dampens excessive neutrophil trafficking to sites of inflammation; reduces neutrophil infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces leukocyte adherence and emigration at 1 nM

Formal name: 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid

Synonyms:  7(S),16(R),17(S)-Resolvin D2|RvD2

Molecular weight: 376.5

CAS: 810668-37-2

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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