An internal standard for the quantification of resolvin D1 by GC- or LC-MS

Resolvin D1-d5 – 10 µg

Brand:
Cayman
CAS:
1881277-32-2
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Item No. 10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718}  

 

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SKU: 11182 - 10 µg Category:

Description

An internal standard for the quantification of resolvin D1 by GC- or LC-MS

Formal name: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21′,22,22,22-d5 docosahexaenoic acid

Synonyms:  17(S)-Resolvin D1-d5|RvD1-d5

Molecular weight: 381.5

CAS: 1881277-32-2

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience

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