A potent anti-inflammatory mediator derived physiologically from the sequential oxygenation of DHA by 15- and 5-LO; reduces human leukocyte transendothelial migration (EC50 = ~30 nM) and limits leukocyte infiltration in a mouse model of peritonitis

Resolvin D1 – 100 µg

Brand:
Cayman
CAS:
872993-05-0
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer (Item No. 13060) of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R)-configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718} Analytical and biological comparisons of synthetic RvD1 with endogenously derived RvD1 have confirmed its identity as matching the natural product.{14569}  

 

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SKU: 10012554 - 100 µg Category:

Description

A potent anti-inflammatory mediator derived physiologically from the sequential oxygenation of DHA by 15- and 5-LO; reduces human leukocyte transendothelial migration (EC50 = ~30 nM) and limits leukocyte infiltration in a mouse model of peritonitis

Formal name: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  17(S)-Resolvin D1|RvD1

Molecular weight: 376.5

CAS: 872993-05-0

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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