An ATP-dependent potassium channel blocker (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2); lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg

Repaglinide – 1 g

Brand:
Cayman
CAS:
135062-02-1
Storage:
-20
UN-No:
Non-Hazardous - /

Repaglinide is a metaglitinide antidiabetic agent that blocks ATP-dependent potassium (Kir6) channels in pancreatic β-cells (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2).{32299} In vivo, repaglinide lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively).{32300} Formulations containing repaglinide have been used to control blood sugar levels in patients with type 2 diabetes.  

 

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Description

An ATP-dependent potassium channel blocker (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2); lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively)

Formal name: 2-ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-benzoic acid

Synonyms: 

Molecular weight: 452.6

CAS: 135062-02-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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