An atypical antipsychotic and dopamine D2 receptor antagonist (Ki = 0.2 µM); selective for the D2 receptor over a panel of 33 receptors

Remoxipride (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
73220-03-8
Storage:
-20
UN-No:
Non-Hazardous - /

Remoxipride is an atypical antipsychotic and dopamine D2 receptor antagonist (Ki = 0.2 µM).{58006} It is selective for the dopamine D2 receptor over a panel of 33 receptors, neurotransmitter transporters, and ion channels at 10 µM but does inhibit the sigma (σ) receptor (Ki = 0.065 µM). Remoxipride (2-20 µmol/kg, i.p.) increases striatal 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in rats.{58007} It inhibits apomorphine-induced stereotypy and hyperactivity in rats with ED50 values of 5.6 and 0.8 µmol/kg, respectively.{58008} Formulations containing remoxipride have previously been used in the treatment of schizophrenia.  

 

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SKU: 30971 - 5 mg Category:

Description

An atypical antipsychotic and dopamine D2 receptor antagonist (Ki = 0.2 µM); selective for the D2 receptor over a panel of 33 receptors, neurotransmitter transporters, and ion channels at 10 µM but does inhibit the σ receptor (Ki = 0.065 µM); increases striatal DOPAC and HVA levels in rats from 2-20 µmol/kg; inhibits apomorphine-induced stereotypy and hyperactivity in rats (ED50s = 5.6 and 0.8 µmol/kg, respectively)

Formal name: 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxy-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 407.7

CAS: 73220-03-8

Purity: ≥98%

Formulation: A crystalline solid

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