A prodrug form of GS-441524; reduces viral titers in primary HAE cells infected with MERS-CoV or SARS-CoV (EC50s = 0.074 and 0.069 µM

Remdesivir – 10 mg

Brand:
Cayman
CAS:
1809249-37-3
Storage:
-20
UN-No:
Non-Hazardous - /

Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524 (Item No. 30469).{45842,45860} Upon entry into cells, remdesivir is metabolized into a nucleoside monophosphate form, which is further metabolized to an active nucleoside triphosphate that induces RNA chain termination and inhibits viral polymerases.{52859} Remdesivir reduces viral titers in primary human airway epithelial (HAE) cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV) or severe acute respiratory syndrome CoV (SARS-CoV; EC50s = 0.074 and 0.069 µM, respectively). It reduces infectious virus production in SARS-CoV-2-infected HAE cells (EC50 = 10 nM).{61140} In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection.{45860} Remdesivir (25 mg/kg) also reduces lung viral titers and lung hemorrhage and improves pulmonary function in mice infected with a chimeric SARS-CoV encoding the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).{61140} Formulations containing remdesivir have been used in the treatment of COVID-19.  

 

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SKU: 30354 - 10 mg Category:

Description

A prodrug form of GS-441524; reduces viral titers in primary HAE cells infected with MERS-CoV or SARS-CoV (EC50s = 0.074 and 0.069 µM, respectively); reduces infectious virus production in SARS-CoV-2-infected HAE cells (EC50 = 10 nM); reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection at 25 and 50 mg/kg; reduces lung viral titer and lung hemorrhage and improves pulmonary function in mice infected with a chimeric SARS-CoV encoding the SARS-CoV-2 RdRp at 25 mg/kg

Formal name: N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile

Synonyms:  GS-5734

Molecular weight: 602.6

CAS: 1809249-37-3

Purity: ≥98%

Formulation: A crystalline solid

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