A selective norepinephrine reuptake inhibitor (IC50s = 8.2 nM) that displays greater than 1

Reboxetine (mesylate) – 25 mg

Brand:
Cayman
CAS:
98769-84-7
Storage:
-20
UN-No:
Non-Hazardous - /

Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively).{24102} It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or dopamine receptors (Kis = 1.1, 129, 1,400, 3,900, and >10,000 nM, respectively).{24102}  

 

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Description

A selective norepinephrine reuptake inhibitor (IC50s = 8.2 nM) that displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or dopamine receptors (Kis = 1.1, 129, 1,400, 3,900, and >10,000 nM, respectively)

Formal name: (2R)​-​rel-2-​[(R)​-​(2-​ethoxyphenoxy)​phenylmethyl]​-morpholine, methanesulfonate

Synonyms:  Davedax|Edronax|FCE 20124|PNU 155950E

Molecular weight: 409.5

CAS: 98769-84-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience

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