A gp130 modulator; increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM); reduces BMP4-induced cellular apoptosis and hypertrophy in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes; reduces cartilage loss in a rat model of osteochondral injury at 4 µg/joint

RCGD 423 – 1 mg

Brand:
Cayman
CAS:
108237-91-8
Storage:
-20
UN-No:
Non-Hazardous - /

RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.  

 

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SKU: 31420 - 1 mg Category:

Description

A gp130 modulator; increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM); reduces BMP4-induced cellular apoptosis and hypertrophy in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes; reduces cartilage loss in a rat model of osteochondral injury at 4 µg/joint

Formal name: N-(4-bromophenyl)-4-phenyl-2-thiazolamine

Synonyms: 

Molecular weight: 331.2

CAS: 108237-91-8

Purity: ≥98%

Formulation: A solid

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