Description
An inhibitor of midasin; inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM); inhibits mdn1 ATPase activity by approximately 40% at 1 µM; inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells; decreases Rsa4 levels in Rix1 particles, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in Nsa1 particles in mdn1-ts fission yeast cells
Formal name: 3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole
Synonyms: Ribozinoindole-1
Molecular weight: 256.3
CAS: 328023-11-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis
