An inhibitor of the Ras-like GTPases RalA and RalB; prevents spreading of murine embryonic fibroblasts

RBC8 – 10 mg

Brand:
Cayman
CAS:
361185-42-4
Storage:
-20
UN-No:
Non-Hazardous - /

RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.{27339} RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).{27339}  

 

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Description

An inhibitor of the Ras-like GTPases RalA and RalB; prevents spreading of murine embryonic fibroblasts, blocks anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibits the growth of H2122 lung cancer xenografts in mice

Formal name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

Synonyms: 

Molecular weight: 424.5

CAS: 361185-42-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Cell Signaling|GTPases

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