An orally available azole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml); inhibits CYP isoforms that are involved in ergosterol biosynthesis

Ravuconazole – 5 mg

Brand:
Cayman
CAS:
182760-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).{30389,30390} Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.{30388} Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).{30392,30391} As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.{30392,30391}  

 

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Description

An orally available azole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml); inhibits CYP isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes

Formal name: 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-benzonitrile

Synonyms:  BMS 207147|ER-30346

Molecular weight: 437.5

CAS: 182760-06-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Environmental

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