A natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM); also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM)

Rauwolscine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
6211-32-1
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).{25653} It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.{25653} Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 µM).{25654,25657,25652} The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.{25656,25655}  

 

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Description

A natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM); also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM)

Formal name: (16β,17α,20α)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester, monohydrochloride

Synonyms:  Isoyohimbine|NSC 407307|α-Yohimbine

Molecular weight: 390.9

CAS: 6211-32-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience

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