A synthetic peptide that contains the sequence PVPPR

Ras Inhibitory Peptide – 500 µg

Brand:
Cayman
CAS:
159088-48-9
Storage:
-20
UN-No:
Non-Hazardous - /

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.{28593} It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.{28593}  

 

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Description

A synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2; specifically blocks the interaction of Sos1 with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases

Formal name:

Synonyms:  ​Sos SH3 Domain Inhibitor​

Molecular weight: 1,170.40

CAS: 159088-48-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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