A histamine H2 receptor antagonist; reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2); inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats from 0.03-3 mg/kg

Ranitidine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
66357-59-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ranitidine is a histamine H2 receptor antagonist.{27474} It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and preventrion of heartburn and gastroesophageal reflux disease (GERD).  

 

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Description

A histamine H2 receptor antagonist; reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2); inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats from 0.03-3 mg/kg ,

Formal name: N’-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine, monohydrochloride

Synonyms: 

Molecular weight: 350.9

CAS: 66357-59-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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