A potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM); has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors

Ramosetron (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
132907-72-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ramosetron is a potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM).{25619,25621} It has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors.{25619} Ramosetron competitively blocks serotonin-mediated contraction of the colon.{25619} It has applications in ameliorating diarrhea-predominant inflammatory bowel syndrome and postoperative nausea and vomiting.{25618,25620}  

 

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Description

A potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM); has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors

Formal name: (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-methanone, monohydrochloride

Synonyms: 

Molecular weight: 315.8

CAS: 132907-72-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Immunology & Inflammation

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