An antibiotic complex; active against clinical isolates of S. aureus

Ramoplanin Complex – 10 mg

Brand:
Cayman
CAS:
76168-82-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ramoplanin complex is a mixture of ramoplanin A1, -A2, and -A3 originally isolated from Actinoplanes that has antibacterial activity.{46853,46854,46855} Ramoplanin complex is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 µg/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 µg/ml).{46854} It inhibits cell wall synthesis in B. subtilis when used at a concentration of 0.5 µg/ml.{46853} Ramoplanin complex is effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice with ED50 values of 0.081, 0.14, and approximately 25 mg/kg per day, respectively.  

 

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SKU: 28189 - 10 mg Category:

Description

An antibiotic complex; active against clinical isolates of S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 µg/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 µg/ml); inhibits cell wall synthesis in B. subtilis at 0.5 µg/ml; effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice (ED50s = 0.081, 0.14, and ~25 mg/kg per day, respectively)

Formal name: ramoplanin A1, A2, and A3 (mixture)

Synonyms:  A-16686|MDL 62198

Molecular weight: 2,554.10

CAS: 76168-82-6

Purity: ≥80% (Ramoplanin A2)

Formulation: A solid

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