The active metabolite of ramipril

Ramiprilat – 10 mg

Brand:
Cayman
CAS:
87269-97-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ramiprilat is the active metabolite of ramipril (Item No. 15558) and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction.{30687,30685} Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling.{30685} In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.{25581,30686}  

 

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Description

The active metabolite of ramipril, an ACE inhibitor (pKi = 9.08 in human heart) that suppresses the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction; interferes with the targeting of B2 kinin receptors to endothelial cell membranes; inhibits MMP-3 and MMP-9 activity in isolated Crohn’s disease fistulas

Formal name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-cyclopenta[b]pyrrole-2-carboxylic acid

Synonyms:  Ramipril Diacid

Molecular weight: 388.5

CAS: 87269-97-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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