An orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay); inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s = 19 and 31 nM in medium containing 10% heat-inactivated FBS or 50% normal human serum

Raltegravir (potassium salt) – 1 mg

Brand:
Cayman
CAS:
871038-72-1
Storage:
-20
UN-No:
Non-Hazardous - /

Raltegravir is an orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay).{26192} It inhibits the spread of HIV-1IIIb infection in MT-4 cell culture with 95% cell culture inhibitory concentration (CIC95) values of 19 and 31 nM in medium containing 10% heat-inactivated fetal bovine serum (FBS) or 50% normal human serum, respectively. Formulations containing raltegravir have been used in combination therapy in the treatment of HIV-1 infection.  

 

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Description

An orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay); inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s = 19 and 31 nM in medium containing 10% heat-inactivated FBS or 50% normal human serum, respectively); is metabolized in the liver primarily by UGT1A1

Formal name: N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide, monopotassium salt

Synonyms:  MK-0518

Molecular weight: 482.5

CAS: 871038-72-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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