A selective estrogen receptor modulator; binds to the estrogen receptor (IC50 = 0.4 nM); exhibits estrogenic activity in bone cells without stimulating breast or endometrial tissue; guards endothelial cells obtained from rat aortic rings against oxidative insult at 1 µM and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg); inhibits Kv4.3 (IC50 = 2 µM)

Raloxifene (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
82640-04-8
Storage:
-20
UN-No:
Non-Hazardous - /

Raloxifene is a selective estrogen receptor modulator (SERM) that binds to the estrogen receptor with an IC50 value of 0.4 nM.{42731} It exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.{16603} Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg).{16603,16602} Raloxifene also inhibits the voltage-gated potassium channel Kv4.3 in an estrogen-independent manner (IC50 = 2 µM).{42733} Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.{16604}  

 

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SKU: 10011620 - 250 mg Category:

Description

A selective estrogen receptor modulator; binds to the estrogen receptor (IC50 = 0.4 nM); exhibits estrogenic activity in bone cells without stimulating breast or endometrial tissue; guards endothelial cells obtained from rat aortic rings against oxidative insult at 1 µM and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg); inhibits Kv4.3 (IC50 = 2 µM)

Formal name: [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone, monohydrochloride

Synonyms:  Keoxifene|LY156758

Molecular weight: 510

CAS: 82640-04-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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