A metabolite of raloxifene; formed from raloxifene via UGT1A1 and UGT1A8; binds to the estrogen receptor (IC50 = 290 nM)

Raloxifene 6-Glucuronide – 1 mg

Brand:
Cayman
CAS:
174264-50-7
Storage:
-20
UN-No:
Non-Hazardous - /

Raloxifene 6-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene (Item No. 10011620).{42731} It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A8. It binds to the estrogen receptor with an IC50 value of 290 nM.{42731,42732} Unlike raloxifene, raloxifene 6-glucuronide does not inhibit the voltage-gated potassium channel Kv4.3.{42733}  

 

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SKU: 27832 - 1 mg Category:

Description

A metabolite of raloxifene; formed from raloxifene via UGT1A1 and UGT1A8; binds to the estrogen receptor (IC50 = 290 nM)

Formal name: 2-(4-hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-6-yl, β-D-glucopyranosiduronic acid

Synonyms:  Ral-6-Gluc

Molecular weight: 649.7

CAS: 174264-50-7

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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