A metabolite of raloxifene; binds to the estrogen receptor (IC50 = 370 nM); inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% at 10 and 30 µM

Raloxifene 4′-Glucuronide – 1 mg

Brand:
Cayman
CAS:
182507-22-8
Storage:
-20
UN-No:
Non-Hazardous - /

Raloxifene 4’-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene (Item No. 10011620).{42731} It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A8, and UGT1A10.{42732} It binds to the estrogen receptor with an IC50 value of 370 nM.{42731} Raloxifene 4’-glucuronide inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% when used at concentrations of 10 and 30 µM, respectively.{42733}  

 

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SKU: 27831 - 1 mg Category:

Description

A metabolite of raloxifene; binds to the estrogen receptor (IC50 = 370 nM); inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% at 10 and 30 µM, respectively

Formal name: 4-[6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]benzo[b]thien-2-yl]phenyl, β-D-glucopyranosiduronic acid

Synonyms:  Ral-4’-Gluc

Molecular weight: 649.7

CAS: 182507-22-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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